Generating New Specific RNA Interaction Interfaces Using C-Loops

Generating new specific RNA interaction interfaces using C-loops.

New RNA interaction interfaces are reported for designing RNA modules for directional supramolecular self-assembly. The new interfaces are generated from existing ones by inserting C-loops between the interaction motifs that mediate supramolecular assembly. C-Loops are new modular motifs recently identified in crystal structures that increase the helical twist of RNA helices in which they are i...

Size-specific ligands for RNA hairpin loops.

The targeting of one mRNA in the transcriptome requires small molecules that bind with substantial affinity and specificity. As such, compounds with specificity for individual RNA secondary structural motifs could be useful for targeting RNA. Described herein is the synthesis of a combinatorial library of 105 dimers of deoxystreptamine and the subsequent identification of compounds with specifi...

Automatically Generating Interfaces for Personalized Interaction with Digital Libraries

We present an approach to automatically generate interfaces supporting personalized interaction with digital libraries; these interfaces augment the user-DL dialog by empowering the user to (optionally) supply out-of-turn information during an interaction, atten or restructure the dialog, and enquire about dialog options. Interfaces generated using this approach for CITIDEL are described.

Generating new Type II protein models using cytochrome c

Generating User Interfaces from

The generation of the dialogue description from an algebraic specification of the application and its restrictions to different user groups are presented. The idea and motivation for the work is that the development of the application and the UI has to go hand in hand. Moreover, the UI should be generated since the programming of UIs is a time consuming and error-prone task. A formal specificat...